Endocrine Abstracts

During fasting neuropeptide Y (NPY) neurons in the mediobasal hypothalamus are activated to increase food intake and to conserve energy. Under conditions of food deprivation, lipid metabolism plays an important role in providing fuel for muscle. We investigated if central NPY affects VLDL-TAG secretion directly via the autonomic nervous system. We measured VLDL-TAG secretion in Wistar rats by an intravenous bolus of tyloxapol to inhibit uptake of triglycerides by peripheral ti...

Background: Recently, we showed that rats on a free-choice high-fat high-sugar (fcHFHS) diet became rapidly obese and developed glucose intolerance within a week. Interestingly, rats on a free-choice high-fat diet (fcHF), although equally obese and hyperphagic as rats on a fcHFHS diet, did not develop glucose intolerance. Glucose tolerance was also unaffected in rats on a free-choice high-sugar diet, although they consumed more liquid sugar than rats on a fcHFHS diet. Hence, t...